Tim Donohoe Group
Hydrogen borrowing | Dearomatisation | Hydride shifts | Total synthesis
Summary
The Donohoe group has many research interests which include the general topics of oxidation & reduction, asymmetric synthesis, C-C bond forming reactions, metathesis and dearomatizing reactions. All of our methodology projects are tested in the area of synthesis in order to seek the limits of the new method and to prepare complex and biologically active compounds of interest.
Overview of the Donohoe Group's principal research areas
Research areas
The use of reversible catalytic redox processes (termed hydrogen borrowing catalysis) is a powerful way of making C-C bonds. The reversible nature of the redox reactions mean that reactive intermediates can be generated, and then captured, in situ. We have recently developed the Ph* group to overcome a number of previous problems centered around a lack of reactivity of the carbonyl substrates and the conditions employed, and this has allowed us to make complex structures or to make single stereoisomers of the products. Our goal is to greatly enhance the range of products that can be formed via enolate chemistry.
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